General information

Hepatodject for dogs: instructions for use, analogues and reviews


Hepatodject as an active ingredient in 1 ml contains: L-ornithine - 15 mg, L-citrulline - 10 mg, L-arginine - 40 mg, as well as excipients: betaine - 15 mg, sorbitol - 200 mg, lidocaine hydrochloride - 1 mg, methylparaben - 0.5 mg, propylparaben - 0.2 mg and water for injection - up to 1 ml.

Hepatodject refers to the group of combined hepatoprotective drugs.

Hepatoprotective effect of the drug due to the properties of its constituent components.

L-ornithine, participating in the Krebs urea-forming cycle (urea formation from ammonia), reduces the level of ammonia in the body, elevated in liver diseases, promotes the synthesis of insulin and somatotropin, activates protein metabolism.

L-citrulline is an amino acid that participates in the urea cycle, contributes to the formation and elimination of urea from the body.

L-Arginine (amino-guanidyl-valeric acid) stimulates cellular metabolism, helps in the neutralization and elimination of ammonia, regulates blood sugar levels and reduces lactic acidosis caused by muscular load, activates the system of nitrogen-containing enzymes synthesizing nitroso group (NO), providing the necessary arteries tone .

Betaine (trimethylglycine) has a choleretic and lipotropic effect, activates metabolic methylation in the liver and the synthesis of phospholipids of cell membranes. Functioning as an alternative donor of methyl groups in the conversion of methionine from homocysteine, it can replace defects in methylation reactions caused by dysfunction of the folate cycle and lack of vitamin B12.

Sorbitol has a detoxification and choleretic effect, provides replenishment of the BCC.

The drug is rapidly absorbed from the injection site, passes histohematogenous barriers and is distributed to all organs and tissues. Partially utilized in metabolic processes, the remainder is excreted by the kidneys (mainly).

According to the degree of its impact on the body, hepatodejekt belongs to low-hazard substances (4th hazard class according to GOST 12.1.007-76), in therapeutic doses it does not have embryotoxic, teratogenic, carcinogenic and sensitizing effects.

Indications for use

Hepatodject is prescribed to animals independently or as part of complex therapy for acute and chronic liver diseases of various etiologies, in order to normalize the function and regeneration of liver cells after endo - and exotoxicosis, somatic and infectious diseases, as well as to reduce the hepatotoxic effect of drugs.

a brief description of

Hepatitis, hepatitis and many other serious illnesses - Hepatodject for dogs can help with all of them. The instructions indicate that it has two main areas: treatment and prevention. Most often, it is given to pets who already have liver problems. It successfully restores this organ. If you take this medicine in courses, you can protect the liver cells from various diseases and normalize its basic functions.

The drug is sold in a small bottle (100mm). It contains a solution with the main active ingredients: L-arginine, L-citrulline and L-ornithine. The medicine can be stored in an unopened package for up to two years; after opening, the shelf life is only 21 days.

Admission Rules

In the instructions for use "Hepatodject" for dogs detailed dosage for all animals. For individuals of this class, 2-5 ml of the drug is sufficient. The procedure can be divided into several main stages:

  1. Preparing a pet for a shot. A few hours before it is not recommended to feed the animal abundantly. Next, you should handle the place for injection with an alcoholic solution (70%).
  2. In the syringe, you need to take the required dose of the drug and gently put it under the skin of the animal.
  3. Then he should be given a drink and left to rest in the supine position.

In total it is enough to make 1-2 injections a day in a small course - from 5 to 7 days. In rare cases, it is necessary to extend the course of treatment up to 14 days.

Possible contraindications and side effects

The instruction "Hepatodject" for dogs indicates that it can be used absolutely for all animals, including cattle. The only contraindication is individual intolerance to the components. It is recommended to pre-test for a possible reaction in the veterinary clinic. If this is not possible, then you must first enter the medicine in a small amount and follow the condition of the animal. If he does not have itching, redness and diarrhea, then you can increase the dosage to the desired value.

The only side effect is an allergic reaction. If it is not possible to cancel injections with medication, then it is recommended to give an antiseptic agent in parallel to the dog.

How to store the drug?

The instructions "Hepatodject" for dogs indicated that the service life is up to two years. It is worth considering that so much medicine will be stored only under the right conditions of storage. Do not allow direct sunlight and excessive moisture. The drug should be in a dry place where the temperature prevails from 5 to 25 degrees. If it becomes necessary to open the bottle, then after each use it should be tightly closed with a lid.

As a rule, 100 ml is too much, if you need to give medicine to one animal. In this case, it is better to buy "Hepatodject" for dogs 20 ml. Instructions for its use are similar.

Possible analogues

"Hepatodject" for dogs, the instructions for which are described above, unfortunately, is not cheap. For a bottle of 100 ml will have to pay about 1000 rubles. Approximately 400 rubles worth of medication dosage of 20 ml.

Accordingly, each caring owner is concerned with the question of whether there are analogues to the “Hepatodject” for dogs. According to experts, this drug does not exist. If necessary, you can replace it with medicine "Heptral", intended for people. Its cost will be several times less. It is strongly not recommended to do such a replacement yourself, you must first consult with a veterinarian. It is necessary to take into account that the "copy" side effects are several times more. This can adversely affect the health of the animal.

For several years now, Hepatodject has been successfully used for dogs (with instructions). Reviews about it are mostly positive. Basically, consumers praise the following:

  • Many claim that this drug can replace a whole course of drug therapy for the liver, consisting of more than three different drugs.
  • Side effects are very rare, after the injection the animal usually feels good.
  • This is an excellent preventive measure that will avoid a huge number of diseases.
  • Instructions "Gepodject" for dogs is quite simple. A person who does not have a medical education can quickly deal with it.
  • The drug is very effective, it is capable of almost completely recovering the liver in seven days, the functioning of which was disturbed for a long time.

There are, of course, negative comments directed towards this medicine. The owners of animals claim that it is quite painful, the animal is experiencing acute discomfort. It is almost impossible to hold it during the injection. In the future, at the sight of the injection, it begins to hide.

Application features

Veterinarians claim that the drug will be effective only if it is given to your pet in accordance with all the rules:

  • The pet's diet should be reviewed before starting treatment with Hepatodject for dogs. Food must be supplemented with vitamins and minerals. You should also give him plenty of water.
  • The course of treatment should be completed. Otherwise, the disease may overtake.
  • In no case should not miss the injection. Otherwise, the drug will act less effectively.
  • Any other medication can be given to the animal no earlier than one hour after the injection.
  • The prophylactic course can be repeated, but not more than once a year and a half.

"Hepatodject" is quite a strong, effective drug. Therefore, it is not recommended to give the dog his own, if there is no serious evidence for this. Illness of the animal, lack of appetite, increased body temperature - all this is the reason for going to the vet. Further, the client will be made the necessary diagnostics, and if necessary, the specialist will prescribe medication, dosage and course of its use.

Dogs have long been true friends of man. The owner is very worried when his animal is sick. Fortunately, there are modern medicines that will help to overcome even the most difficult ailment.

Doses and method of use

Hepatodject is administered slowly to the animal intravenously or deeply intramuscularly in the following doses:

Single dose

Course duration


1 - 2 times a day for 5 - 7 days



Cattle (cattle adult)

Pigs, sheep (adults)

Lambs, pigs

Calves, foals

1 ml per 5 - 10 kg body weight

At the discretion of the veterinarian, the course of application may be increased to 14 days.

Pharmacological properties

Hepatoprotective effect of the veterinary drug is determined by the components that make up its composition.

L-ornithine is involved in the Krebs urea-forming cycle, reduces the level of ammonia in the animal's body, which is elevated in liver diseases, activates protein metabolism, promotes the synthesis of somatotropin and insulin.

L-citrulline - an amino acid involved in the cycle of urea formation, contributes to the process of formation and elimination of animal urea from the body of the animal.

L-Arginine stimulates the process of cellular metabolism, regulates blood sugar levels, helps in the neutralization and elimination of ammonia, reduces lactic acidosis, which is caused by muscular load, and also activates the system of nitrogen-containing enzymes that synthesize nitrosogroup (NO) to provide the necessary arterial tone.

Betaine (trimethylglycine) activates cell membrane phospholipid synthesis, has choleretic and lipotropic effects, and metabolic methylation in the liver. Betaine (trimethylglycine) can replace defects in methylation reactions, which cause a disruption in the functioning of the folate cycle and a lack of vitamin B12, and also functions as an alternative donor of methyl groups in the conversion of methionine from homocysteine.

Sorbitol has a detoxification and choleretic effect, and also provides a BCC replenishment.

Veterinary drug Hepatodject is rapidly absorbed from the injection site, passing histohematogenous barriers and being distributed to all organs and tissues. It is utilized in metabolic processes, as well as excreted through the kidneys.

According to the degree of impact on the animal's body, Hepatodject is a class of low-hazard substances and in therapeutic doses does not have a teratogenic, embryotoxic, sensitizing and carcinogenic effect.

special instructions

Slaughter of animals for meat is allowed not earlier than one day after the last use of the Hepatodject veterinary preparation. The meat of animals that were involuntarily killed before the expiration of the day after the last application of Hepatodacter can be used as food for fur animals.

It is prohibited to use milk for food purposes, obtained from animals during the treatment period and during the day (two milkings) after the last administration of the drug. The above milk after heat treatment can be used in animal feed.

Storage conditions

It is necessary to store Hepatodject in a closed package, in a dry place, without access to direct sunlight, and also without access for children and animals. Hepatodject storage should be separated from feed and food. Store Hepatodject at a temperature between +5 ° C and +25 ° C. The shelf life is 2 years from the date of manufacture, after opening - no more than 3 weeks.

Composition and release form

The drug belongs to the hepatoprotectors, as it is used to restore the functions of the liver and regenerate the cells of this organ. The medicine is produced by a Russian manufacturer, the Api-San company, which develops and manufactures veterinary drugs. It is a ready solution for injections. Does not require dilution or mixing with other components before being introduced into the animal. Convenient release form - one of the main advantages.

Externally, Hepatodject is a clear, non-sediment liquid. At emergence of turbidity or foreign impurities it is impossible to use means. Liquid is packaged in dark glass bottles of 20 or 100 ml. Packed vials with rubber caps and rolled with aluminum foil.

The active ingredients of the drug are amino acids:

In addition, the composition of the hepatoprotector includes excipients that enhance the action of the active substances, stop inflammation, reduce pain and perform other functions. As auxiliary components used:

  • sorbitol,
  • betaine
  • lidocaine hydrochloride,
  • propyl paraben,
  • metal paraben.

One of the main additional components is purified water.

Instructions for use

The solution for injection can be administered in several ways:

  • subcutaneously (more suitable for small dogs),
  • intramuscularly
  • intravenously.

When using the intravenous method, fluid is injected very slowly.

According to the instructions for use, a single dose of Hepatoject for dogs is 2-5 ml. Per day, make 1 or 2 injections, depending on the weight and age of the animal, the degree of development of the pathology and general health. The course of treatment is usually 5-7 days, but in some cases it can be extended to 2 weeks.

Rules of application

For effective treatment, it is important to follow simple rules and recommendations:

  1. For injection, use disposable sterile syringes.
  2. Follow all aseptic rules.
  3. Do not skip the medication, otherwise its pharmacological properties will decrease. If this does happen, the injection should be given at the earliest opportunity and the treatment regimen previously prescribed by the doctor should be resumed.
  4. The drug can be used in combination with other medicines.

There are no data on incompatibility of Hepatodject with other drugs or feed additives.

Contraindications and side effects

According to GOST, the medicine is classified as a low-hazard substance. It has no contraindications, with the exception of intolerance to the components. Do not use the drug and in the event that intolerance is in history. Restrictions regarding the age and weight of the animal Hepatodject has no. The veterinarian individually determines the need for treatment, doses, duration and regimen.

Side effects of the drug does not cause. Sometimes allergic reactions can occur. In this case, treatment with the hepatoprotector should be discontinued. To eliminate allergic reactions that may manifest as, itching, redness, rash, or other means, prescribe antihistamine medication.

Although lidocaine is a part, the first injection can be quite painful. In the future, the animal's organism adapts and transfers injections more easily.

Precautions and storage rules

Although the hepatoprotector is a safe product, it should be immediately washed off if it comes in contact with mucous membranes or skin. Hands should be washed after the injections. In the event of an allergy should consult a doctor.

It is important to follow simple storage rules:

  1. Temperature range should be between +5 and + 25 ° C.
  2. The drug should be stored away from sunlight and in a dry place.
  3. The solution for injection should be out of reach for children.
  4. Do not store the product near food and food.

After opening the bottle, the drug can be used for 3 weeks.

The cost of Hepatodject for dogs depends on the volume of the bottle:

  • 20 ml - 500-630 rubles,
  • 100 ml - 920-1100 rubles.

Owner reviews

Angelina, mistress of the South Russian Shepherd Dog:

“When piroplasmosis was detected in our Martha (that’s the name of the dog), they were shocked. After testing at the hospital, we were given an injection of Piro-stop and some other drugs, and Metrogil and Hepatodject were prescribed home. Do injections intramuscularly. It was evident that the dog hurt, but she courageously endured. After a few days, Martha became better, and the test results returned to normal. Repeatedly I read positive reviews about this hepatoprotector, happy to join them. ”

Lydia, the owner of the bulldog:

“After treating inflammation of the urinary tract with antibiotics, liver counts worsened. The dog lost its appetite, she did not want to play and spent the whole day lying. The doctor prescribed a Hepatodject injection. Препарат дешевым не назовешь, но зато эффективный. Уже на следующий день псу стало намного лучше, он стал кушать любимый корм. При повторной сдаче анализов по завершению курса (кололи 5 дней) все результаты были в норме.I think that this domestic hepatoprotector helped us to get rid of intoxication caused by antibiotics. ”

Veterinarian reviews

Nikolay, the vet in metropolitan clinic:

“Hepatodject is a modern and very effective drug that helps the liver recover from illness and taking toxic drugs. Usually the first injection is very painful, but then the animals tolerate the injections more easily. ”

Valentina, veterinarian with 7 years of experience:

“I consider Hepatodject the most effective hepatoprotector. I assign it to my patients for over a year. During this time, there have never been any side effects or allergic reactions. Dogs do not particularly like these injections because of the pain, but they have a great liver support. I prescribe medicine both for liver pathologies, and for infectious diseases or while taking strong medications. ”

Composition, release form and packaging

The solution for injection is available in glass bottles of 20 and 100 ml in vials, sealed with a rubber stopper with an aluminum cap.

The composition of Hepatodject includes (indicated in 1 ml): 15 mg - L-ornithine, 10 mg - L-citrulin, 40 mg - L-arginine, 15 mg - betaine, 200 mg - sorbitol, 1 mg - lidocaine hydrochloride, 0 , 5 mg - methylparaben, 0.2 mg - propylparaben, up to 1 ml of water for injection.


The single dose for adult cattle is 50-100 ml. For calves (animals up to six months), this dose is calculated depending on body weight: 1 ml of solution for 5-10 kg of animal body weight.

Sheep and Pigs

A single dose for adult pigs and sheep is 10-15 ml. In the case of Hepatodject for treating piglets or lambs, it is necessary to inject at most 3-5 ml of solution at a time.

A single dose of the solution, which is used to treat horses, is 50-100 ml. Applying Hepatodject for foals, you should count 1 ml of solution for 5-10 kg of body weight.

Dogs and cats

Following the instructions for the use of Hepatodject for cats, to achieve the desired therapeutic effect, you should enter no more than 2-5 ml at a time. Pregnant cats, as well as feeding offspring, the use of the drug is allowed only under the supervision of a specialist.

An identical dose of the drug is recommended by the instruction and for the treatment of dogs. Hepatoject cats and dogs should be injected into a vein, or, as deeply as possible, subcutaneously or intramuscularly.

Precautions and special instructions

Meat and milk of animals, which the drug was introduced less than a day ago, is strictly prohibited to eat. At the same time, these animal products are completely harmless as animal feed.

Hepatodeject is a fairly strong and effective drug, therefore it is not recommended to give it to animals independently. Before you prick Hepatodject to a cat, dog, or farm animal, you should always consult a veterinarian.

Shelf life and storage conditions

The product must be kept out of the reach of children and animals. Avoid direct sunlight and high humidity, the optimum temperature - from 5 ° C to 25 ° C. The tool must not be stored together with food and in places accessible to children.

Shelf life of an open bottle - 3 weeks. The contents of the closed vial are usable for two years from the date of manufacture. After the expiration date, use of the drug is prohibited.

In Hepatoject, there are two directions: prevention of the disease and its treatment. Taking prophylactic hepatodojects can protect the liver from various diseases. For animals in which this organ already works with impairments, Hepathoject is an effective medication that allows normalizing its basic functions.

Reviews about "Hepatodject (solution) for cats and dogs":

Matured, strong, Orlik suddenly fell ill. At first I lost my appetite, and when I started to lose weight, I had to turn to a veterinarian. A specialist, examining a foal, noted the yellowness of proteins, the yawn of an animal. The final diagnosis, made after a blood test, simply struck - poisoning with the baptismal, which affected the liver.

Specialist proposed to treat Orlik with Hepatodject. The severity of the foal dictated daily 2-time vaccination. The veterinarian made injections personally, observing the course of the disease. Orlik was fixed in the stall, tied his hind legs, the specialist did injections to the thigh muscles. The treatment took a couple of weeks.

At the end of the term, Orlik noticeably “cheered up”, he felt the beneficial effect of “Hepatodject”. I note, the groundberries - the rarest plant in our area. I had to carefully examine the pastures to prevent re-poisoning.

He also warned his neighbor, a horse breeder, who said that there was an effective “Hepatodject” that was helping out animals in cases of poisoning affecting the liver. The drug helps dogs and cats.