General information

NITOX - 200 instructions for use


In modern veterinary medicine, antibiotics are widely used - substances of complex composition, including substances of various organic materials that can inhibit and stop the existence of harmful microbes.

The most common in animal husbandry are diseases of the respiratory and digestive organs, which are often caused by accumulations of microorganisms. They are able to shake animals fairly by penetrating their organs. And the wider the possibilities of the antibacterial agent, the more successful the treatment will be.

To broad-use drugs include antibiotics, among which the tetracycline family leads. For several years, Russian veterinarians have been using the Nitox 200 tetracycline drug, patented in Russia, when treating animals for infections.

Characteristics of the drug

The drug Nitoks 200 has a characteristic odor, comes in the form of a solution for injections, is a slightly viscous clear liquid with a brownish tint.

The treatment component is oxytetracycline, its presence in one milliliter of solution is 200 mcg (concentration 20%). At the base of the solution distilled water, in addition to the liquid present:

  • magnesium oxide, performing the function of an acid quencher,
  • catalyst N, N-dimethylacetamide,
  • rongalite used in the synthesis of drugs
  • substance monoethanolamine, well absorbing acidic gases.

Packaged tool in bottles with capacity from 20 to 100 milliliters. Stored in a container closed from the sun or in a refrigerator at a positive temperature of up to 8 degrees for no longer than one year.

The bottles are supplied with labels informing about the manufacturer, the method of use and the amount of the medicine in the package, the period and storage conditions. Each package is accompanied by instructions explaining the use and dosage of injections.

The price of the drug is relatively low. It varies by region and approximately one small bottle can be bought. at the price of 50 rubles. Analogs are drugs with the same active substance: Oxytetracyclines 100, 200, and 200 LA, its hydrochloride, Oksilong, Tetrazole LA, and Tetralong-20.


The long-term effect of the drug is due to the binding of the active substance with the magnesium compound. After the injection, the drug is actively absorbed from the injection area to other tissues and is concentrated there in maximum quantities in about an hour. The treating substance Oxytetracycline dihydrate is active relative to almost all the main types of bacteria. Impact on them, it turns out, by inhibition of the synthesis of protein cells of microorganisms :

  • Escherichia, salmonella and spirochete.
  • Chlamydia, Streptococcus and Staphylococcus.
  • Corynebacteria, actinobacteria and fusobacteria
  • Erysipelotric, clostridium and pasteurella.
  • Psevdomonad and rickettsia.

The process of active action of the drug continues in the blood of the animal. three days. The drug is removed from the body mainly through urine and bile, and, if the animal is lactating, then with milk. Nitox 200 is classified as hazard class 3 (medium hazard).

Instructions for use Nitox 200

The drug can be used both for therapy and for the prevention of a variety of viral diseases. Since Nitoks 200 is an antibiotic, it is treated with it. infectious diseases animals, including cattle (cattle).

These are mainly diseases whose viruses do not tolerate the presence of oxytetracycline:

  1. Diseases of the respiratory tract, including atrophic rhinitis and pneumonia.
  2. Hemorrhagic septicemia (pasteurellosis) or fever with intoxication.
  3. Chlamydial (enzootic) or viral abortion in sheep.
  4. Inflammation of the mammary gland in cows and rabbits (mastitis).
  5. Keratoconjunctivitis.
  6. Inflammatory joint disease purulent arthritis.
  7. Hoof rot in cows, horses, sheep, pigs.
  8. Abscess and peritonitis.
  9. Infections after injury and after childbirth.
  10. Tick-borne disease anaplasmosis.
  11. Re-infection after past viral diseases.

The effect of the drug in the blood lasts for three days, and often this time turns out to be enough for recovery. The animal is injected once and deeply into the muscles, the dose of the drug is determined by the body weight based on 0.1 ml of solution per kilogram.

And in one point of the injection you can not enter more than 20 ml for cattle, 10 - for pigs and 5 ml - for small animals like sheep, goats and rabbits. If you want to enter a dose that exceeds the allowed amount in one place, then injected at several different points.

Re-injection allowed no earlier than three days. If the scheduled re-injection time is missed, it is necessary to deliver the injection without delay and at the dose previously prescribed. It is unacceptable to compensate for the missed time by increasing the dosage.

Application Restrictions

The result of the injection can be redness of the skin (erythema) and itching, it does not last long, disappears without additional treatment. In case of an allergic response to an injection, calcium chloride can be administered to the animal.

Manifestations of overdose are expressed in the absence of the desire to eat or inflammation of the injection site. Upon detection of these signs, the injection of the drug is stopped.

Eliminate the effects of the same remedies. based on calcium compounds. It is unacceptable to use Nitoks 200 in the following cases:

  • kidney diseases
  • fungal mycosis,
  • pregnant females and calves, piglets and kids up to three months,
  • intolerance to tetracycline drugs.

Definitely can not apply injections regarding cats and dogs. As for horses, then, despite the ban instructions, the practice of use is available, and the feedback about it is positive. The combined use of the drug with penicillin antibiotics reduces the effect of its action.

Use of cattle processing products. Slaughter for meat after treatment of an animal with this preparation is allowed in three weeks. If the slaughter of an animal occurred earlier, then it is used as food for predators or for making bone meal.

Sheep's milk, cow and goat after thermal processing can be added to animal feed. Person should not consume it, in any form before the expiration of the week.

Application Reviews

The vast majority of livestock breeders who have used Nitox 200 in their practice agree that the drug works effectively and rarely needs repeated injection. Moreover, in addition to the recommended for use breeds of animals, the reviews say that they use it and in the treatment of rabbits, pigeons and horses.

“Despite the ban on the instructions to use Nitox 200 for horses, I did it, because there was nothing else to do. And the horse rose to his feet! "

"I have a dovecote, and I add Nitox 200 to pigeons in the drinkers, this contributes to the fact that they do not get sick, although their numbers are considerable."

“There are no veterinarians in our village, we treat ourselves. It so happened that the rabbits suddenly became poorly eaten and completely passive. Read the instructions, and decided to try to prick them. Dosage was done on the recommended principle. After three days, everyone was okled, it helped. ”

Release form, composition and packaging

Injection transparent, slightly viscous, brown.

Excipients: magnesium oxide, N, N-dimethylacetamide, rongalite (sodium formaldehyde sulfoxylate), monoethanolamine, distilled water.

It is packaged on 20, 50, 100 ml in glass bottles, corked by the rubber traffic jams strengthened by aluminum caps. Each unit of packaging is supplied with instructions for use of the drug.

Pharmacological (biological) properties and effects

Antibacterial drug of tetracycline group.

Oxytetracycline dihydrate, which is part of the drug, has a bacteriostatic effect, active against most gram-positive and gram-negative bacteriaincluding Streptococcus spp., Staphylococcus spp., Corynebacterium spp., Clostridium spp., Erysipelothrix spp., Pasteurella spp., Fusobacterium spp., Salmonella spp., Pseudomonas spp., Actinobacteria spp., Escherichia sfpp, 3. ., and Spirochaetes spp.

The mechanism of action of oxytetracycline is to suppress the synthesis of protein microorganisms. The prolonged (prolonged) effect of the drug is due to the oxytetracycline dihydrate complex with magnesium. When i / m administration of oxytetracycline dihydrate is rapidly absorbed from the injection site and reaches maximum concentrations in organs and tissues 30-50 minutes after administration. Therapeutic level of antibiotic in the serum is maintained for 60-72 hours. Oxytetracycline dihydrate is eliminated from the body mainly with urine and bile, in lactating animals - partly with milk.

Nitox ® 200 according to the degree of impact on the body belongs to moderately hazardous substances (3 hazard class according to GOST 12.1.007-76).

Application procedure

The drug is used in animals once deeply in a / m dose of 1 ml of injection for 10 kg of animal weight (20 mg of oxytetracycline dihydrate per 1 kg of weight). If necessary, the injection of the drug is repeated after 72 hours.

Maximum dose for administration to one point of the body: cattle - 20 ml small animals - 5-10 ml. If the volume of the injected solution is more than this, it should be injected into animals in several places.

Features of the action at the first use of the drug and its cancellation was not detected.

When skipping the introduction of a repeated dose of the drug, the use should be resumed as soon as possible in the prescribed doses and in the same pattern. Do not use a double dose to compensate for the missed.

Side effects

Erythema and pruritus, which quickly disappear and do not require treatment, can occur at the injection site. If a sustained allergic reaction occurs, it is recommended to administer calcium preparations (calcium chloride, calcium borgluconate), symptomatic therapy. With long-term use Tetracycline group drugs may experience complications due to the development of candidiasis (skin and mucous membrane lesions), as well as septicemia (blood infection) caused by the candida fungus Candida albicans.

With overdose drug in an animal may be a failure of the feed, an inflammatory reaction at the injection site. In this case, you must stop the introduction of the drug. If necessary, it is recommended in / in the introduction of calcium preparations (calcium chloride, calcium borgluconate), symptomatic therapy.

Special instructions and measures for personal prevention

Pregnant and lactating females drug is used with caution under the supervision of a veterinarian.

Nitox ® 200 should not be used simultaneously with corticosteroids and estrogen.

In connection with a marked decrease in the antibacterial effect of oxytetracycline, the drug is not recommended to be used simultaneously with penicillin and cephalosporin antibiotics.

Slaughter of animals for meat is allowed no earlier than 28 days after the administration of the drug. The meat of animals that were involuntarily killed before the expiration of these periods is used to feed carnivores.

Milk of dairy animals should not be eaten and subjected to technological processing within 7 days after the administration of the drug Nitox ® 200. Such milk can be used after heat treatment for feeding animals.

Personal preventive measures

During the work with the drug Nitoks ® 200 it is necessary to follow the general rules of personal hygiene and safety measures provided during the work with medicines. During work, it is forbidden to drink, smoke and eat. After work, wash hands with soap and water.

People with hypersensitivity to the components of the drug should avoid direct contact with the drug Nitoks ® 200. In case of accidental contact with the drug on the skin or mucous membranes, they should be washed with a large amount of tap water. In the event of an allergic reaction or in case of accidental ingestion of the drug in the human body, you should immediately contact a medical institution (you should have the instructions for use of the drug or a label with you).

Empty vials from the drug should not be used for domestic purposes, they must be disposed of with household waste.

Storage conditions Nitoks ® 200

The drug should be stored in sealed packaging manufacturer, in a dry, protected from direct sunlight, out of reach of children, separately from food and feed, at temperatures from 0 ° C to 20 ° C.

Unused drug is disposed of in accordance with the requirements of the legislation.

Biological characteristics and description

The basis of the drug Nitox 200 is oxytetracycline dihydrate. Auxiliary components of the drug include: distilled water, Mg oxide, monoethanolamine, rongalite.

It is necessary to know that the licensed preparation Nitox (analog of sacox) is a liquid solution for i / m injections of a brownish tint, with a specific smell.

The effect of oxytetracycline is aimed at suppressing the synthesis of proteins of microscopic organisms and bacteria. The long-term effect of the drug is the interaction of oxytetracycline dihydrate with Mg (magnesium). The main advantage of oxytetracycline during injections is its immediate absorption and accumulation of the substance in soft tissues, muscles and organs for a short period of time (up to 50 minutes). The productive effect of the medicinal product is maintained for 72 hours after its introduction into the infected organism of the animal. The antibiotic is derived in a natural way: urine, bile, milk.

Side effects on animals

In some cases, in places where the drug is administered to animals, rapid itching and erythema are observed, which do not require additional medical intervention. Prolonged use of the drug may cause complications. in the form of sepsis and candidiasis, a temporary lack of appetite. Allergies caused by the use of an agent are treated with calcium injections (calcium-chlorine, borgluconate).

Do not use the product in conjunction with penicillins and cephalosporins, as well as with corticosteroids.

Drug reviews

Lost the appetite in rabbits, they became inactive. I decided to use the tool Nitox. A few days later they recovered, it helped.

I add the drug to pigs for prophylactic purposes. Do not get sick, that makes me very happy.

In a hopeless situation, I decided to use Nitox 200, despite the contraindications of instructions. The horse recovered.

The main advantages of the antioxidant Nitox are its effective prolonged effect on the animal’s body and its availability (the price of the drug varies between 45–55 p.). Without exaggeration, it can be argued that Nitox is the flagship in the market for antibacterial agents for veterinary medicine.

What does the drug consist of? Release form and storage rules

Nitox 200 is a development of the Russian company NITA-FARM, which specializes in the creation and production of pharmaceutical preparations for veterinary medicine. The substance is available in liquid form, as a solution for injections. It looks slightly viscous, transparent, with a dark shade and a specific smell. Oxytetracycline is the active ingredient in Nitox. The number 200 in the name of the drug suggests that 200 ml of the antibiotic are contained in 1 ml of liquid. In addition, the composition contains additional substances: distilled water, magnesium oxide, rongalite, etc.

The manufacturer packs Nitoks in dark glass bottles, which helps protect the drug from the sun's rays. The volume of contents - 20, 50 and 100 ml. Cost - from 60 to 250 rubles. Each tank is sealed with a rubber stopper and an aluminum cap.

All packages are supplied with instructions for use. Along with the rules for treating livestock, it contains recommendations for the storage of Nitox. In addition to sunlight, this antibacterial agent should be protected from heating above +25 ° C. The lower limit of the temperature regime is + 5 ° С. In closed form Nitox is stored for 3 years from the date of issue, in the open - no more than 4 weeks. The medicine is kept away from food, livestock feed, and securely hidden from children.

Attention! NITA-FARM also releases Nitox Forte. In addition to a similar antibiotic at a concentration of 300 mg per 1 ml, this drug contains a non-steroidal anti-inflammatory component - flunixin. With the help of Nitoks Forte, veterinarians treat the diseases of the gastrointestinal tract, respiratory, urogenital systems and a number of other diseases in animals.

Who and what diseases prescribe medication

A broad-spectrum antibiotic has a bacteriostatic effect on Salmonella, Chlamydia, Streptococcus, Staphylococcus, Pasteurella, and other harmful microorganisms. This means that Nitoks does not destroy bacteria, but contributes to the delay of their growth and prevents further reproduction. Due to this property, the medicine successfully copes with such ailments:

  • mastitis,
  • respiratory diseases
  • sepsis,
  • boils, ulcers,
  • inflammation of the peritoneum,
  • purulent arthritis,
  • footrot,
  • pasteurellosis,
  • as well as secondary infections with viruses, etc.

With the help of the drug will be able to cure large and small horned animals (cows, sheep, goats), as well as pigs. Restrictions on the use of drugs for the young there. Pregnant and lactating females must be observed by a veterinarian during therapy.Animals that have a history of renal failure, fungal diseases and intolerance to the components of the tetracycline group, cannot be pounded with Nitox. Also, instructions for use warns: antibiotic is prohibited to horses, dogs and cats.

Features of use and reviews of farmers

The method of application is the same for all animals that are allowed medicine: 1 ml of the drug per 10 kg of weight. The drug is injected deep into the muscle. As a rule, only one injection is required, since Nitox is effective from 60 to 72 hours. If a repeated dose is still required, it is administered after 3 days.

  1. The peak of antibiotic concentration in the body of a sick animal occurs within 30-50 minutes. after the injection.
  2. At one point on the body of the cow and other cattle allowed to enter a maximum of 20 ml Nitoks. Sheep, goats and pigs - 5-10 ml.
  3. If an animal needs more medicine by weight, several injections should be given in different places.

Reviews confirm the effectiveness of the drug. But farmers warn: allergic reactions are possible in animals. This probability is spelled out in the instructions for use. Sell ​​Nitox without a prescription. However, before starting treatment, the owner should consult a veterinarian.

Indications for use

When do they use Nitox for animals? The instructions indicate that the drug is used for the treatment or prophylactic measures to prevent infectious diseases, but only those that are caused by pathogens susceptible to oxytetracycline. And also for the prevention and treatment of secondary developing infections in the background of viral diseases.

In pigs, the drug is used to treat pneumonia, pleurisy, erysipelas, purulent arthritis, umbilical sepsis, mastitis, rhinitis, abscesses, and postpartum infections.

In sheep and goats, foot rot, mastitis, peritonitis, pneumonia, enzootic abortion and wound infections are treated.

Excellent proved "Nitox 200" for cattle.

Its use is possible in the case of pneumonia, mastitis, anaplasmosis, pleurisy, hoofed rot and other diseases of the extremities, diphtheria, conjunctivitis, wound infections.

One milliliter of the drug contains 200 mg of the active active ingredient - oxytetracycline. The composition also includes some other excipients.

Pharmacological properties

The active ingredient of the drug - oxytetracycline - has a bacteriostatic effect on many gram-positive and gram-negative bacteria, including acting on streptococci, clostridia and staphylococcus, salmonella, actinobacteria, chlamydia, spirochetes, pasteurella, fusobacteria and others.

The drug has a long lasting effect due to the complex of oxytetracycline and magnesium.

With intramuscular injection, the active substance is instantly absorbed from the injection site and in 40-60 minutes reaches the maximum possible concentration in organs and tissues. The therapeutic level of the drug in the blood is maintained for three days.

Oxytetracycline is excreted with body fluids (urine, bile), and in newly born animals, partly with milk.

According to GOST, which distributes medicines for animals to various hazard classes, "Nitox" refers to substances that are moderately hazardous (this is hazard class 3).


The main factor limiting the use of "Nitox" is hypersensitivity to the active substance or other components of the drug.

In addition, the simultaneous use of the drug and corticosteroids, estrogen is not recommended. Since penicillin and cephalosporin antibiotics can significantly reduce the antibacterial effect of tetracycline, their combined use is prohibited.

You can not use "Nitoks" for the treatment of horses, dogs, cats and other pets with renal insufficiency.

Restrictions during and after taking the drug

There are some restrictions on the use of products of cattle and small ruminants, which was introduced "Nitoks" for animals. The instruction indicates that slaughter for meat can be carried out no earlier than 20 days after using the drug. If the animal was forced to be killed before the expiration of this period, then it is allowed to produce meat and bone meal or given to feed carnivores.

Milk from cows, sheep and goats is not eaten and is not processed for at least a week after the injection of "Nitox". However, during this period milk can be thermally processed and used for feeding animals.

Personal preventive measures

Any work that uses drugs for animals, including Nitox 200, must be carried out with mandatory personal hygiene and safety instructions. Work with the drug is necessary only in gloves. In case of accidental ingestion of the product into the eyes or on the skin, it is necessary to wipe it off with a cotton swab, and rinse the site of ingestion with plenty of running water.

Keep the drug should be in a closed and dark place out of reach of children.

Dosage and method of use

The indisputable advantage of "Nitox" is the need for a single injection. And only in rare cases, the injection can be repeated after 72 hours.

The drug is injected deep inside the muscle. The dose is set at the rate of 1 ml of "Nitox" per 10 kg of animal weight.

There are restrictions for the introduction into one point of the body "Nitoks 200". For cattle, the use of 20 ml of the drug is the maximum dose for administration to one place on the body, for pigs - 8-10 ml, for small cattle - 5 ml.

Drug reaction

After the introduction of the medication is possible manifestation of allergic reactions. A slight erythema and itching may appear at the injection site. In most cases, such reactions take place quickly and without interference. However, in extreme cases or in case of overdose, intravenous calcium supplementation is recommended.

How much is the drug "Nitoks"? The price of this tool varies depending on the region and market place, but on average it ranges from 45 to 55 rubles per bottle of 20 ml. Produced by the company "Nita-Farm".


First, the drug has a very wide spectrum of action and is very effective against most infections of farm animals. Secondly, the cost of treatment is beneficial, since in the vast majority of cases the course of treatment is 1 injection. Thirdly, the patented production technology allows you to maintain quality at the highest level. And, finally, a special composition and dosage form can provide antibiotic therapy for several days.

So, in this article was considered in detail the drug "Nitoks" for animals, instructions for its use, especially the introduction and dosage. Currently, "Nitoks" is the market leader in veterinary drugs due to its undeniable advantages.

The mechanism of action and active ingredient, pharmacological properties of Nitoks 200

The active ingredient of the drug Nitox is oxytetracycline dihydrate, a tetracycline antibiotic used not only for the treatment of animals, but also in traditional medicine (in particular, for pneumonia, bronchitis and other infectious diseases of a bacterial nature). As the name suggests, Nitox contains 200 mg of active ingredient per 1 ml of the preparation. In addition, the composition of the dosage form includes a component of an auxiliary nature - a complex solvent of magnesium oxide, rongalite, monoethanolamine, which allows to significantly prolong the effect of the drug on the causative agent of the disease.

The mechanism of action of oxytetracycline on microorganisms is that, like other tetracyclines, this antibiotic interferes with the proliferation of bacteria and causes a complete retardation of their growth (the so-called bacteriostasis), and this substance can have such an inhibitory effect not only on bacteria susceptible to the effects of antibiotics ((Gram (+)), but also on bacteria that can withstand such drugs for a long time ((Gram (-)).

The list of bacteria susceptible to oxytetracycline is very wide. This includes various staphylococci, streptococci, Corynebacteria, Clostridia, Salmonella, Pasteurella, Erisiperotriks, Fuzobakterii, Pseudomonads, Actinobacteria, Chlamydia, Escherichia, Rickettsia, Spirochetes.

The above properties of the veterinary drug Nitox determine the indications for its use against such bacterial diseases as pneumonia, pasteurellosis, mastitis, keratoconjunctivitis, purulent arthritis, hoofed rot, atrophic rhinitis, abscesses, chlamydia abortion, metritis-mastitis-agalactia syndrome, umbilical sepsis, anaplasmosis, peritonitis, pleurisy and many others. In addition, nitox is used for various respiratory diseases, as well as infections that occur after injury and childbirth. Viral diseases are not known to be treated with antibiotics, but against them, animals can have complications of a bacterial nature, which are successfully overcome by the injection of the drug nitox 200.

The drug is very quickly absorbed into the organs and tissues of the animal, reaching the required concentration within half an hour after intramuscular injection. The amount of active ingredient required to achieve a therapeutic effect is stored in the serum for up to three days and is excreted in the bile and urine.

Precautions and storage conditions

The drug Nitox 200 is not recommended to be combined with estrogenic and corticosteroid hormones, as well as with other antibiotics, in particular the penicillin and cephalosporin groups (in the latter case, the effectiveness of the effect of the drug on the causative agent of the disease is sharply reduced).

Contraindication is also renal failure in an animal, as well as individual intolerance to antibiotics of the tetracycline group.

According to the level of influence on the body, the drug belongs to the third class of danger. (moderately hazardous substances). It is necessary to work with it taking into account the hygienic requirements and safety regulations recommended by the manufacturer, as well as those observed when using any other veterinary drugs.

Like other potent drugs, Nitox 200 should be kept out of the reach of children and separated from other drugs. Storage conditions - dark dry place, temperature in the range of 0 ° С - + 20 ° С.

After the expiration date (18 months from the date of manufacture), the drug should be destroyed.